Arifureta Shokugyou de Sekai Saikyou (WN) - Volume 1 Chapter 2

Before going to college, an ordinary high school student went to celebrate and got drunk. When he woke up, he found himself in a completely different world. There was a big sect, the approaching sect entrance examination, a slum where his body’s previous owner lived, and a shared memory about a missing young girl.

Yuan was born with an incurable illness that left him blind at a young age and crippled a few years later, rendering everything below his head useless. Deemed hopeless and irredeemable, his parents quickly gave up on him, and the world ignored him.

He was the continent’s strongest and most revered alchemist, Ye Zifeng. He was under one person and above millions. However, due to an unpredictable event, he had died. After his rebirth, he had become the supertrash of the Ye family and suffered disgrace. To make matters worse, he had an argument with his fiancé that led to the break off of his engagement. In this second life, he will work to change his own destiny. He vows to return to the peak of the world, trample on those who laughed at him and rewrite his legacy!

- Description from Novelupdates

Year 24XX. With several hundred years of improvements, virtual reality has become more mature. It had gradually become humanity’s second world. Socializing, working, studying and other everyday things could all be done while sleeping.