In Naruto with the Flame-Flame Fruit - Chapter 410: - : Haku

220 years ago, in the legendary Dragon Demon War, Hero Azell ended the war by killing the evil Dragon Demon race’s King Atein. He was able to save the population, but as a consequence, he was cursed. While he was dying, the high magician suggested a gamble that might save his life.

Qin Aofeng, a third-generation descendant of the great and prestigious Qin Family, was just as famous as his genius big brother Aotian, but was famed in Qin City for being the “Good-for-nothing Seventh Young Master.”

The compound is perilous, the clan is full of conflict. Before her rebirth, she dressed as a male, her birth a mystery. Because of her lack of talent, she was thought of as a worthless member of the clan. After her rebirth, she walked onto the path of a strong person, and lived on the continent like a fish in water.

Until one day at the capital city of the empire, the spear of the patriarch pointed to her young uncle that she always treasured, the “young male” that had always been undistinguished stood out, and astounded everyone, becoming a peerless genius. Ever since then, countless males and females became made for … …

The vast ancient forests, the deep bogs shrouded in back mist, the desolate and endless desert, the mountains and plains without any border where the magical beasts moved unhindered, this was a vast magical world.

- Description from Novelupdates

In 2040, The Earth was bathed in powerful radiation when a star went supernova, this radiation granted 50% of humans superhuman abilities but also created a nightmare for them as animals, insects, and carnivorous plants were mutated and became overpowered with intelligence, human started teetering on the brink of survival, a boy with no powers and no father, with a mother in a coma, seems destined for obscurity, but one night changed his life, with a new found hope to cure his mum from the everlasting sleep—Gene Elixir— he went on on a journey that would reshape his destiny...~Voracious Sovereign... Gene Devourer...Pray you won't be devoured by this power you wield which hunger is insatiable~~You call yourself an opportunist... But... you aren't free. A hungry man is not a free man...~

Three years into Qin Yu's marriage, his wife and in-laws all hated him.