Naruto: Reborn as Orochimaru - Chapter 279

She, Xue Fanxin, a famous medical genius in the 21st century, had transmigrated into the body of the dumb daughter of the Grand Duke.

I have calculated for people before I was born, and I have all five yin, and I am born with fierce ghosts. A knowledgeable gentleman said that I will not live to be seven years old. After death, I will cultivate blood-clothed little ghosts to harm people.

In order to save me, my grandmother married me a child-in-law, so that I had an Ann birthday, although I later discovered that the daughter-in-law and sister-in-law are not human…

I have been lingering and panting since I was a child, and I have been accustomed to accepting it, but my grandmother was killed.

For this reason, regardless of karma, I inherited my grandmother’s job of raising ghosts and vowed to send everyone who killed her to hell.

- Description from MTL

The world ends in a single moment.When the Mass Outbreak Event shatters reality, portals tear open across the globe, unleashing monsters that drive civilization to collapse. As cities burn and order crumbles, a game-like System activates across humanity, granting survivors levels, skills, and abilities, and forcing the world into a brutal new set of rules.Eighteen-year-old Jagger Ashton is dragged into this new reality where monsters are only part of the danger. Humans, twisted by power, fear, and desperation, prove just as deadly. Every encounter pushes Jagger closer to the edge, testing his sanity and the fragile line between control and corruption.Jagger begins to uncover a terrifying truth.The Outbreak was not just an invasion. It was a selection process.The System is preparing the world for something far worse.And whatever is coming… it wants strong survivors.To survive what lies ahead, Jagger must confront the power festering inside him and choose whether to master it or surrender to it entirely.

The challenges a female cultivator had to overcome on her life journey were countless.