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... he wouldn't necessarily lose his mind. However, there would certainly be mental side effects. The intense spiritual power required to wield the Mangekyō would undoubtedly affect his psyche.

When using the advanced abilities of the Mangekyō Sharingan, the body is put under incredible strain. Over time, side effects such as myopia, eye bleeding, and severe physical pain are almost guaranteed. The sheer power of the ocular jutsu overloads the body's capacity to manage the strain, leading to ...

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