MTL - Doctor’s Life Simulator-Chapter 346 New drug simulation again, smoking cessation drug bupropion: Zyban…

After the successful operation, all the directors naturally looked at Qin Lang differently and were amazed.

In the next few days, Qin Lang continued to cooperate with and assist Academician Zhong to perform several operations, involving the experimental group and the control group, a dozen cases.

The next stage of the entire research project is led by Academician Zhong, and the rest of the directors and experts participate, and Qin Lang is the first assistant to complete this stage.

After the last operation, Academician Zhong and the chief physician of the Cardiac Surgery Department of Xiehe Hospital called Qin Lang to the office.

"Qin Lang, your recent surgery has been done perfectly. Academician Zhong and I are both very satisfied. If you are interested, you can directly exchange and study in our hospital for a month. I also have several surgical procedures here. I would like to invite you You join in."

Like the chief physician of Union Medical College Hospital, the research techniques and topics are naturally very difficult, and the requirements for the level of participants are even more stringent.

Therefore, the chief physician was able to make such an invitation, and he had already valued Qin Lang very much.

Of course, in addition to helping him with his research, the most important thing is that the director of Xiehe Cardiac Surgery wants to let Qin Lang feel the atmosphere of Xiehe Hospital through this month's exchange and study. The academic atmosphere, as well as the top talent pool, also treat patients with the most research value in the country and have the most cutting-edge research directions!

The director of Xiehe Cardiac Surgery is very confident. After a month, even if he doesn't invite him, Qin Lang will have the idea of ​​​​not being inseparable.

Academician Zhong also said to Qin Lang in a friendly manner: "Qin Lang, consider it."

To tell the truth, Qin Lang really wanted to stay for the invitation of the two elders. After all, no doctor could refuse Xiehe's invitation.

However, Qin Lang has more important things to do now. He needs to win the business battle with Pfizer for Ming's Pharmaceutical Group.

Seeing Qin Lang's hesitation, Academician Zhong thought he was worried about the opinions of the original unit, and directly dispelled Qin Lang's worries:

"Qin Lang, don't worry, as long as you're willing. I'll explain the situation to you personally at the First Hospital of Hecheng City."

"Academician Zhong, Director, I actually want to stay, but I have no choice. Recently, I need to go back to Hangzhou to develop a new drug, which concerns the future of many people. I can only say sorry."

Academician Zhong and the director did not expect that Qin Lang would be such a reason. In this case, they can only wait until Qin Lang is done.

"Qin Lang, since that's the case, then we won't be **** others. However, I hope you will come to our department to study and communicate after you complete your own new drug research and development. The door of Xiehe Hospital is open for you at any time!"

Academician Zhong expressed unprecedented sincerity. He really appreciates and likes Qin Lang.

"Thanks to Academician Zhong and Director for their appreciation, I will definitely. When I complete my mission, I will definitely come to Xiehe Hospital, the top medical school in China for further study!"

After the three of them chatted for a while, Qin Lang left Xiehe Hospital.

After returning to Zijingang First Hospital, Qin Lang directly started the simulation of new drug research and development. Over this period of time, he has obtained enough simulation points.

[Ding, do you need to consume 3 life simulation points to activate the smoking cessation drug bupropion: ZybanSR, the first stage of research and development simulation? 】

Qin Lang directly clicked on the simulated drug and watched the description of the drug research and development laboratory:

[Drug name: Bupropion. Psychiatric drugs, central nervous system drugs, raw materials, organic chemical raw materials...]

【Uses: It is a safe and effective antidepressant drug that can be used clinically. It has a very good smoking cessation effect and can greatly improve the success rate of active smoking cessation. 】

After a general understanding, Qin Lang chose to start!

[Ding, consume 3 life simulation points to start the first stage of research and development of bupropion! 】

【New drug development in progress...】

【Bupropion: 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride; 1-(3-chlorophenyl)- 2-[(1,1-Methylethyl)amino]-1-propanone...]

【Chemical structure: O】

[Molecular weight: 239.74]

【Melting point: 233-234°C】

【Boiling point: bp.00552°】

【Acidity coefficient: pKa7.0(Uain)】

【color: White】

[Entering the first stage, compound simulation synthesis...]

【While stirring...】

【Cooling...】

【Reflux, Heating, Hydrolysis, Filtration, Crystallization...】

...

[Ding, congratulations to the host, the first stage of compound synthesis has been completed. Have you obtained the synthetic route of the compound and mastered the best synthetic route? 】

Of course, Qin Lang chose to obtain it immediately. Countless information entered his mind, and Qin Lang directly grasped the synthetic route of this compound.

Moreover, the main physical parameters of bupropion can be viewed directly from the pharmaceutical laboratory.

[No, consume 1 life simulation point to synthesize the first tube of reagents in the drug laboratory? Remarks: This reagent can be brought back to the real world]

Qin Lang naturally consumed another life simulation point. It has to be said that the research and development of new drugs is really a high-cost investment.

In the virtual laboratory, under the new top-notch equipment, Qin Lang started the preparation operation and tried to synthesize it by himself.

[Ding, consume 1 life simulation point to start preparing the compound of bupropion for the first time. 】

In the virtual laboratory, Qin Lang quickly started the operation and tried to synthesize it by himself.

Various instruments and reagents kept appearing in Qin Lang's hands. With concentration, a small tube of bupropion finally appeared in Qin Lang's hands.

[Ding, do you want to consume 6 life simulation points to start the second stage of research and development of bupropion? 】

Looking at this consumption, Qin Lang also smiled bitterly. He was really reluctant. It seems that after completing several stages of research and development of this smoking cessation drug, he needs to accumulate more life simulation points.

Next, after Qin Lang completed the two-stage simulation, he went to the new company to carry out the first-stage experiment. According to the time line in the simulation world, but the time is not waiting for me.

Qin Lang is the first person in charge of the new company. Naturally, no one dares to object to his arrangement. The R&D team with Qin Lang as the core operates in an orderly manner.

This time, in addition to exposing Pfizer's ugliness, Qin Lang intends to launch bupropion: ZybanSR as soon as possible!

When Qin Lang was secretly preparing for the new drug of bupropion, Pfizer Pharmaceuticals in the United States, the R&D laboratory, was also intensively developing new drugs. It was precisely according to the ideas and direction of Mingshi Pharmaceutical Group, an improved smoking cessation drug. :tix!

According to Pfizer's plan, the brand-new drug will be launched in three months.

Although there are some side effects, as long as the first-mover advantage is occupied, there are ways to make up for it later. Moreover, in the future, these drugs with hidden side effects will be pushed to China, and Pfizer does not care at all.

After all, the Huaguo market is an emerging market with low requirements and blind faith in Pfizer.

Pfizer and the FDA are the top standards in the industry, and they do not and dare not question them.

After the first batch of drugs is launched, it will not be long before an improved version will be available. Unbeknownst to God!

...

...

When Qin Lang and Pfizer were competing in drug development.

Harbin Medical University Second Hospital, Vice President's Office.

Dean Zhang sat at the desk, looking at a document, sometimes frowning, sometimes clenching his fists.

After a while, a middle-aged doctor in his forties walked in. Professor Liu Bin, a top expert in cardiac surgery at the Second Hospital of Harbin Medical University, is also a giant in the field of heart transplantation in China.

Dean Zhang saw Professor Liu, and his words were very respectful, and he asked very politely:

"Professor Liu, I heard that you are going to the Imperial Union Hospital for a heart transplant recently?"

"Yes, President Zhang also knows." Professor Liu did not hide it. After all, among the senior doctors in China, flying knives are very popular, and no hospital will have trouble finding a doctor because of this.

Hearing Professor Liu's affirmative answer, Dean Zhang frowned. If it was normal, he really didn't care. Professor Liu went to the imperial capital to fly a knife.

However, now, by coincidence, he has encountered a more important matter. He needs Professor Liu to stay on guard and organize an operation that will leave a deep mark in the history of heart transplantation.

However, the operation cost of a heart transplant is basically around 200,000-500,000, especially for a top domestic expert like Professor Liu, who has at least 400,000 jumps for one appearance.

Therefore, directly asking Professor Liu to give up the flying knife and stay behind to prepare for the operation in the hospital would be a waste of money. Dean Zhang naturally couldn't make a strong request, so he could only persuade Professor Liu to give up voluntarily.

After all, Dean Zhang is an old fox who has been in management for many years, and he is even more handy at playing the emotional card. He got up and started to make tea, and chatted seemingly aimlessly.

"Professor Liu, what do you think of the Cardiac Surgery Department of the Second Hospital of Harbin Medical University?"

Dean Zhang made the tea, poured a cup for Professor Liu, and then filled it up himself, took a sip, and said sullenly.

"The Second Hospital of Harbin Medical University is naturally a pioneer in domestic heart transplantation. The history of heart transplantation in the Cardiothoracic Department of the Second Hospital of Harbin Medical University can also be regarded as the development history of heart transplantation in China."

For heart transplantation, Professor Liu is of course full of confidence. In his opinion, the heart transplantation of the Second Hospital of Harbin Medical University is the top in the country, and he is also the top heart transplant surgeon in the Department of Cardiac Surgery of the Second Hospital of Harbin Medical University. .

After taking another sip of tea calmly, President Zhang continued to sigh with emotion: "Yes, the heart transplant surgery in our hospital has really gone through a process of starting from nothing, from obscurity to fame in China."

Putting down the teacup, Dean Zhang looked at Professor Liu deeply, and said in a long tone, "It's not easy~"

Professor Liu also nodded: "Yes, it's really not easy for our heart transplant operation in the Second Hospital of Harbin Medical University to get to where it is today. It took several generations of efforts from the exploration stage to the development stage to the current mature stage. ."

Professor Liu began to recall carefully, and he has a lot of knowledge about the entire development history:

Exploratory stage: In 1956, Professor Zhao Shijie, the pioneer of the cardiothoracic surgery department of the Second Hospital of Harbin Medical University, a famous surgical expert, successfully carried out the research on the dog head transplantation experiment, and obtained the best record of survival for 5 days and 4 hours after transplantation. my country's first in the field of organ transplantation.

In the early 1980s, Professor Xia Qiuming of the Second Hospital of Harbin Medical University, a well-known expert in cardiothoracic surgery in my country, resolutely aimed at this risky high-tech project, leading personnel to search for literature and understand the history and current situation of foreign heart transplantation, which was the first in China to start a challenging high-tech project. In the field of heart and heart-lung transplantation, he has successively determined the basic surgical methods of heart transplantation, and explored effective treatment methods for anti-rejection after heart transplantation; at the same time, he has done a lot of clinical and basic monitoring of acute rejection after transplantation The research has laid a solid foundation for the work of heart transplantation in my country.

On April 26, 1992, Xia Qiuming was the chief surgeon. Hundreds of experts from the Second Hospital of Harbin Medical University and more than 20 departments worked together to perform the first case in Northeast China for Yang Yumin, a farmer from Dongfeng Town, Taiping District, Harbin City, a patient with dilated myocarditis for many years. One year later, Yang Yumin returned to the society after allogeneic heart transplantation and was able to support himself.

Yang Yumin has lived a healthy life for 18 and a half years after surgery, becoming the longest healthy survivor after a heart transplant in mainland China. Yang Yumin passed away on November 20, 2011 due to chronic rejection...

However, the development stage of the Second Hospital of Harbin Medical University: With this as a starting point, my country's heart transplantation work has entered a new clinical stage from a low-grade state.

In February 1994, the second year after the first heart transplant, the Second Hospital of Harbin Medical University successfully performed an allogeneic heart transplant for Yu Wenfeng, an excellent teacher from Maoershan Town Middle School, Shangzhi City, Long Province.

In 2000, the Second Hospital of Harbin Medical University successfully performed a heart transplant for 57-year-old writer Yang Mengyong, completing the oldest heart transplant case in my country.

After the operation, Yang Mengyong's silver hair turned into black hair, and his face was radiant.

In Yang Mengyong's book "Let's Talk About Live", he fully expressed his gratitude to the Second Hospital of Harbin Medical University for giving him a second life. "Repaying the society" with their own actions is the biggest wish of several heart changers.

The third stage is the mature stage: while vigorously developing clinical operations of cardiac surgery, experts from the Department of Cardiac Surgery of the Second Hospital of Harbin Medical University realized that cardiopulmonary bypass and myocardial protection are the basis for the development of cardiac surgery, and repeatedly conducted a large number of animal experiments. , A series of studies on myocardial protection methods such as ischemic cardiac arrest, potassium-containing cold crystalloid cardioplegia, cold blood potassium cardioplegia, and warm blood potassium cardioplegia have made breakthrough progress. Advanced, further established the leading position of the Department of Cardiac Surgery of the Second Hospital of Harbin Medical University in China.

Today, aortic sinus aneurysm repair, complete pulmonary vein drainage correction, coronary artery bypass grafting, mitral valve replacement, aortic valve replacement, etc. have become routine operations in the Second Hospital of Medical University.

Hearing Dean Zhang's knowledge of heart transplantation in the department, Professor Liu was naturally excited and emotional.

"Professor Liu, you are now the bearer of the flag in our hospital's mature stage. With the joint efforts of you and the department, the success of Rastalli surgery, Fantan surgery and Bantall surgery marks the second hospital's cardiac surgery in complex congenital heart disease and other diseases. The field of surgical treatment of macrovascular disease has reached a new level."

"This year, more than 1,000 cardiac surgeries have been completed, including all common heart diseases and complex heart diseases in infants and young children, minimally invasive surgery for small body weight, valve replacement and plastic surgery, on-pump and off-pump bypass surgery, major vascular surgery, and organ transplantation. etc. The success rate of surgery is 96%. Cardiac surgery has become the first in the three northeastern provinces and a key discipline with certain influence in the country and abroad. It is the only company in the country that can carry out heart transplantation, lung transplantation, total aortic arch replacement, low The heart surgery center is a heart surgery center with many high-precision technologies, such as treatment of complex congenital heart disease, coronary heart disease bypass, biological valve mechanical valve replacement, and thoracoscopy minimally invasive heart surgery.”

Hearing Dean Zhang's praise, Professor Liu also straightened his chest, which is what he is most proud of.

Seeing that the atmosphere was almost rendered, Dean Zhang sighed faintly:

"Originally, this time, our hospital has an opportunity to once again leave a strong mark in the history of heart transplantation in the whole country and even in the world. It's just that Professor Liu happened to be going to perform a flying knife, alas, it's a pity."

"What does President Zhang mean? What opportunities can we make for our department to advance domestically and internationally? In front of the department's honor, I can completely put this flying knife away."

Professor Liu's mind was agitated at the moment, and his mind was full of collective honor. He directly put aside the matter of flying knife and gave up the surgery fee of 400,000 yuan.

"Does Professor Liu still have any impression of Ye Jian?"

"Ye Jian?" Professor Liu pondered in his mind, "You mean that Ye Jian who was "transformed" by the then director of cardiac surgery ten years ago."

"Yes, this time, I would like to invite you to organize more than 20 related departments and hundreds of medical workers to challenge another limit in the medical history of our country, the "second heart transplant", which is to replace Ye Jian with his third heart transplant. A heart, the third wonderful life!"

Hearing President Zhang's idea, even an authority in the field of heart transplantation, Professor Liu was a little shocked.

"The Guard is Here"

Ye Jian needs a second heart transplant. The main reason is that after the heart transplant, there are two problems that the world still cannot solve: one is chronic rejection, and the other is the vascular disease of the graft.

But now Ye Jian has two factors at the same time, especially for a long-lived heart transplant recipient like him.

Dean Zhang handed Ye Jian's latest physical examination information to Professor Liu.

After flipping through the information, Professor Liu's whole face also became very serious and solemn:

"Ye Jian, the main problem in the heart is the coronary arteries. The arteries supplying blood to the heart are severely diseased, stenotic and occluded, resulting in severe insufficiency of blood supply to the myocardium. At the same time, there is a fatal arrhythmia, that is, frequent ventricular tachycardia. A severe tachyarrhythmia that can develop into ventricular fibrillation, leading to sudden cardiac death. Ye Jian has induced ventricular fibrillation twice."

"President Zhang, the situation is very dangerous. If the ventricular fibrillation is not rescued in time, it will lead to death."

Dean Zhang nodded: "Ye Jian suffered two ventricular fibrillation in Chengdu, Sichuan two months ago and one month ago, and he suffered cardiac arrest and lost consciousness. After timely rescue, his life was saved from the hands of the **** of death. It has been delivered now. In our hospital, he had 100 ventricular tachycardia within 24 hours of his heart test, and each ventricular tachycardia may develop into ventricular fibrillation. In other words, he is in danger of cardiac arrest every second. If Without a heart transplant, he could have died at any time."

Professor Liu looked at the data again: "Ye Jian's chronic rejection caused severe coronary artery lesions. In the past three years, he has also combined diabetes and aggravated the changes in the coronary arteries, and because he has been taking anti-rejection drugs all year round, the blood vessels will also be damaged. , the combination of these factors makes the coronary disease response extremely severe and rapid."

"With the current level of medical development in the world, this arrhythmia and myocardial ischemia cannot be solved by other means, and the only way to save Ye Jianhua's life again is to have a heart transplant again."

After reading it, Professor Liu made the same judgment as Dean Zhang. Ye Jian's only way out now is a second heart transplant.

"So Professor Liu, this second heart transplant operation, in our hospital, only you can complete this limit task."

Dean Zhang filled Professor Liu with a cup of tea and continued, "Professor Liu, my idea is that starting today, you will immediately start organizing cardiac surgery, cardiology, nephrology, urology, ultrasound medicine, rheumatology and immunization. Experts from more than ten disciplines, including the Department of Medicine, will consult to formulate a comprehensive plan.”

"After all, Ye Jian's heart attack was sudden and complicated. Ye Jian's chronic rejection caused serious coronary artery lesions. In the past three years, he has been complicated with diabetes and aggravated the changes in the coronary arteries. Taking anti-rejection drugs all year round will also affect the blood vessels. There is damage, these factors lead to the extremely serious and rapid development of his coronary lesions. At the same time, Ye Jian is accompanied by unavoidable severe renal function damage and liver function damage after heart transplantation, and the success rate of the operation is seriously reduced. ."

"President Zhang, you really gave me a huge problem, but it's also a huge opportunity."

After all, Professor Liu is one of the top three people in the domestic heart transplant operation. Although he knows that it is extremely difficult, he still has the spirit to challenge it.

"Yeah, so Professor Liu, this time I will mobilize the resources and manpower of the whole hospital to cooperate with you. If necessary, I can invite experts from other schools you know to cooperate and assist."

Dean Zhang also understands the difficulty of secondary heart transplantation. In the past 30 years, there have been less than ten secondary heart transplantation operations that have been documented in the world, and there is no documentary record. As for the domestic situation, it is still blank and there is no precedent. can learn from.

That is to say, this time, the surgical plan completely needs to rely on Professor Liu to take the lead and the elite forces of the United Public Department to create the first plan. It has not been verified and is not mature. Even Professor Liu is very uneasy.

After all, compared to the first heart transplant, the second heart transplant is much more difficult than the first transplant. First, the patients with the second transplant are in far worse physical condition than the first transplant patients.

Ye Jian has experienced ventricular fibrillation twice, leading to loss of consciousness, severe kidney damage, liver damage, and poor blood conditions in the body... Multiple factors have led to a continuous decline in the success rate of the operation.

Second, the hearts that have been transplanted are so sticky after more than a decade, the heart environment in the patient is almost completely unknown. Third, the patient has already stripped the pericardium during the first transplant, and the risk of damage to the heart in the second thoracotomy is several times higher than that of ordinary people.

"According to the preliminary judgment, Ye Jian's time is running out, and there are only four days left for your surgery. Therefore, within three days, you must make all preparations for the second heart transplant."

Seeing that the time was right, Dean Zhang broke through the last layer of window paper.

Of course, Professor Liu was completely attracted by this task, both for the honor of the department and for his own pursuit.

"President Zhang, then I will arrange and design Ye Jian's surgical plan now."

After thinking about it for a while, Professor Liu immediately came up with a preliminary plan. He planned to convene more than a dozen departments of the Second Hospital of Harbin Medical University, a hundred experts, staff, and eight medical groups, including the preoperative preparation group and the operation group. Conduct surgical research, and prepare facilities, medicines, and material support.

Soon, top experts from more than a dozen medical departments such as cardiac surgery, cardiology, anesthesiology, ICU, nursing, ultrasound medicine, radiology, laboratory, hematology, nephrology, urology, rheumatology and immunology were in Liu. Under the mobilization of the professor, he came to the consultation room.

Regarding Ye Jian's second heart transplant, the first general meeting of the hospital was held.

At the same time, Professor Liu took advantage of the gap to call Director Dong of Union Hospital~www.novelbuddy.com~ Director Dong, sorry, I have an important project here, the heart transplant that was originally scheduled. I can't come. You find another expert to fly the knife again. "

Director Dong, one of the chief physicians of the Cardiac Surgery Department of Union Medical College Hospital, was immediately dumbfounded after listening to Professor Liu's words:

"Professor Liu, you are kidding me. This is not already discussed. You will come to our hospital tomorrow to perform surgery. I am ready for everything. You also know that the patient is older and the difficulty of heart transplantation is It's very high. That's why I invited you to be the chief surgeon. If you don't come, where can I find a doctor who is as powerful as you."

Director Dong himself has also had heart transplants, but they were all relatively young patients. This time, the patient was a big man in the imperial capital. He was already very old and had underlying diseases. Top Professor Liu.

"It's only one day, Professor Liu, it's hard for me to do this."

Director Dong's tone almost brought tears.

"Director Dong, I can't help it either. The patients I have now are more dangerous and more important than those on your side. I'm sorry. In addition, I believe that there are still many experts outside of your Xiehe heart. No, you can go. Let's take a look at Fuwai Hospital. Well, I won't tell you, I'm going to have a consultation here."

Professor Liu hung up the phone directly.

Director Dong listened to the busy tone on the other end of the phone and almost collapsed. If he had been a few days earlier, he would have been able to find someone, but now the time is too urgent. As far as he knows, the Cardiac Surgery Department of Xiehe can perform such a difficult heart transplant. The chief physicians are all lined up.

"It's really not possible, I'll go on my own?" Director Dong struggled, "No, I'm still close to it, unless there is a powerful one to help me."