MTL - Since 1981 Health School-Chapter 407 miserable aspen

  Chapter 407 Miserable Aspen Company

  Stockholm Airport, among a group of yellow-haired and white-skinned people, there are two Chinese people who are particularly obvious.

  White people passing by took a few extra glances at them and heard them speak English. Although their clothes were not extravagant, they were neat and generous. They thought they were from Bangzi Country or Japanese.

   After all, Chinese people were still rare at this time. Even if they were seen, they could be identified just by the Chinese tunic suit and serious facial expression.

  Lan Lijuan asked about some facilities at her husband's airport and the national conditions of Sweden in English that she was not too familiar with.

  Chen Qi held his wife's hand tightly, and while walking to get the luggage, he also answered his wife's inquiries in English.

  Since Xiangjiang started connecting planes, Chen Qi asked Lan Lijuan to communicate in English the whole time, whether it was between the two of them, or going to a convenience store to buy something, or colluding with a flight attendant.

  After graduating from technical secondary school, Lan Lijuan studied English every day with the encouragement of her boyfriend Chen Qi.

   Later, Chen Qi also took advantage of the opportunity of going abroad to buy a lot of video tapes in English, including movies and TV shows, just to let his wife practice her spoken English.

  Of course the video is a serious video, there is no shouting: "mygod", "comeonbaby"

  After several years, Lan Lijuan has been able to fully read English periodicals and materials, but oral English has always been her weakness. After all, it is still difficult to learn oral English in an English environment.

  Just by watching the video, I can fully understand what I heard, but it still takes a lot of effort to speak.

   Just taking advantage of this opportunity to go to Sweden, Chen Qi decided to let his wife's spoken English quickly catch up.

  No matter what era, those who say that English education is not important, and even push the country to abolish the main English subject in primary and secondary schools, are either stupid or bad.

   Chen Qi is now the popular spicy chicken of ICPF, and what he enjoys is VIP pick-up treatment.

  When the couple came to the exit, the organizers of the ICPF annual meeting were already waiting. After shaking hands, they got into the car and drove quickly towards the hotel.

  Yes, Chen Qi mainly came to Sweden to attend the ICPF annual meeting this time, and he came early, and did not come out with the Hua Guo delegation.

  Because he came to Sweden this time, in addition to attending the annual meeting, he also had a private itinerary, which was also the reason why he took Lan Lijuan to go abroad.

  That is for his wife's career, he needs to discuss a cooperation with the Swedish Asrila Pharmaceutical Company.

  At this time, at the headquarters of Asrila Company, Chairman Denilson was looking at the latest drug produced by the company with a frown.

  This is a stomach medicine. In order to develop this medicine, the company has been researching for 15 years from 1970 to 1986.

  The funds invested have accumulated up to 500 million US dollars.

  Asrila, among the many pharmaceutical companies in Europe and the United States, can only be regarded as second-rate at best. The company's finances are not too rich, and the 500 million US dollars will kill the company.

  Regarding pharmaceutical research and development, there is a "rule of 10", that is, spend 10 years, invest 1 billion US dollars, and have a 10% success rate.

  So R&D funds account for the majority of pharmaceutical companies, and eat up most of the profits. As a result, among the 10 subjects studied, only 1 was successful in the end.

   If this drug is successful, it may be in a monopoly position, and your drug is unique in the world, then you will make a fortune.

  If all 10 research topics fail, sorry, the company will bear the loss.

   But Aslila did not have such good luck.

  Because he developed a stomach medicine, and throughout the 1970s and 1980s, there were two medicines that dominated the stomach disease market in the world, one was cimetidine and the other was ranitidine.

   These two mainstream drugs compete very fiercely with each other.

  The problem is that the boss and the second are engaged in competition, and often the third and fourth are finished first.

  So Denilson is very troubled. How can the drug produced by his company compete with cimetidine and ranitidine?

   You must know that cimetidine is produced by SmithKline, while ranitidine is produced by Glaxo, both of which are pharmaceutical giants in England.

   Neither the size of the company nor product marketing is comparable to the second-tier company Asrila.

   What's more terrible is that the drug newly invented by Asrila is the same type of gastric acid suppression drug as cimetidine and ranitidine.

  Although the laboratory report obtained by Denilson is certain, the newly invented drug is far stronger than ranitidine or cimetidine in terms of acid suppression.

   But so what?

  How to get patients to accept a new drug so that they are willing to pay for it involves the issue of how to promote it, which requires a lot of advertising costs and buying a large number of top international gastroenterologist platforms.

   This is another huge expense, and Denilson doesn't have the courage to fight the two big pharmaceutical giants.

  And there is another disadvantage of Asrila's new drug, that is, their research and development costs are too high, which leads them to increase the price of the drug. The current price is 10 times that of ranitidine.

  Even if your curative effect is better than ranitidine, but your price is 10 times that of it, except for the rich, the general public will definitely choose cheaper drugs.

  Why is the cost of the new Asriella drug so high? It can only be said that this is a product full of disasters.

  In 1970, AstraZeneca launched a gastrointestinal research program, intending to inhibit gastric acid secretion through similar synthesis of anesthetics. Based on lidocaine, this research synthesized a variety of related compounds.

  The compound did have a good effect on gastric acid suppression in rats, but it was later found that compound H81/75 was ineffective on humans, which made the research almost stranded.

  By 1972, the gastric acid suppression project was restarted with a new method, and a compound CMN131 was developed to inhibit gastric acid secretion, and it was found that this compound had acute toxicity.

   Yes, the project can only continue to study.

  In 1973, Asrila Company discovered the relatively safe benzimidazole H124/26, but unfortunately, this compound has been covered by other companies’ patents, and it was useless again.

   After finally developing the metabolite H83/69, it was found that there is long-term chronic toxicity that causes goiter and thymus atrophy.

  Finally, it is imperative to modify the structure of H83/69 again, thus obtaining the compound H149/94.

  This time it was successfully developed. It can be seen that the process is difficult. Any problem in any step may lead to the failure of the entire project.

  The application for a new drug was submitted in 1980, entered the substantive experimental stage in 1982, and the product was finalized in 1986.

  For 15 years of research and development, it cost a total of 500 million U.S. dollars. Remember, this was 500 million U.S. dollars in the 1970s and 1980s, which will kill Aslila.

  Asrila Chairman Denilson sat in the main seat, listening to the reports of his subordinates.

   "We have decided to participate in the World Pharmaceutical Exhibition held in China, and we will do our best to promote it at the conference. The plan is as follows..."

   "We have reached a cooperative relationship with Professor Segel of Karolinska University Hospital, and he will help us promote the latest drugs at this year's International Society of Gastroenterology..."

   "We also plan to invest 20 million US dollars in European Sens, and invest in advertising in major countries..."

  The reports from the subordinates became more and more positive, but Denilson had a headache because none of these suggestions was new.

  What he needs is a blockbuster, explosive publicity, and a unique perspective so that the public can quickly remember and understand this drug.

  But the promotion plans provided by my subordinates are the same as boiled frogs in wet water. Not only are they not innovative, but they are also very formulaic.

  For example, the sponsors behind the "International Society of Gastroenterology" are either Glaxo or Smith Kline. Only these two big dogs in the field of gastric medicine can spend a lot of money.

  "International Society of Gastroenterology" (WCOG), this is the world's mainstream medical association, with more than 50,000 members worldwide, and thousands of people gather at each annual meeting.

  In terms of scale and influence, it is not comparable to primary schools such as ICPF or FSSH.

  The two pharmaceutical giants have spent a lot of money to sponsor this conference, and they will definitely give preferential treatment to the stomach medicine promotion of these two companies. How can it be the turn of Asrila?

  Similarly, the products of these two companies have long been widely used clinically, and they have also established good cooperative relations with some of the most famous digestive disease experts and doctors in the world.

  This kind of relationship has a lot of benefits to export, and it needs to give a lot of dollars, which is equivalent to an "alliance relationship".

   This is an extremely strong network, and pharmaceutical companies and well-known doctors are all communities of interest.

  Now Asrila wants to intervene horizontally, which is equivalent to a third party intervening, and the possibility of success is relatively small, because the rich and powerful people give money readily and give more.

   Fighting for financial resources? Asrila is the younger brother.

  When Aslila was worried about the promotion of new products, Chen Qi and Lan Lijuan had already arrived at the hotel.

  Professor Dewey, the president and vice president of the ICPF Society, Prof. Johnson from England, and Prof. Hashimoto Takeshi from Japan are already waiting.

  It is impossible for the three presidents to wait for the subordinate directors for a while in other societies. When a person reaches a certain level, he must pay attention to his style.

  But there is no way, Chen Qi is really amazing. From the beginning of the three new cleft lip and palate surgeries that amazed the venue, to the previous "tubular rhinoplasty", they are all pioneering surgeries.

  He is so powerful, and humble, and willing to separate his achievements from others. Such a good man without ambition is worthy of the various presidents of ICPF to win over and establish a good personal relationship.

  Especially Professor Hashimoto Ken, when he saw Chen Qi coming in, he went up and gave him a hug:

   "Chen Sang, you are late, we have been waiting for you for a long time, haha, Doctor Lan, we meet again."

   Lan Lijuan also hurriedly smiled and nodded in greeting: "Professor Hashimoto, I never expected to see you again so soon."

  Ken Hashimoto stayed in the Fourth Hospital of Yuezhong for 2 weeks for tubular nose surgery. In order to establish a friendship with Chen Qi, he often went to Chen Qi's house to have dinner, so he was very familiar with Lan Lijuan.

  Dewey had been to Huaguo twice before, and he was no stranger to Chen Qi's wife, so he took the initiative to say hello:

   "Chen, your beautiful wife is probably afraid of you messing around outside, so she came to supervise you personally. It's over, I dare not invite you to the bar tonight."

  Chen Qi blinked: "It's okay, I can sneak out while my wife is asleep."

  hahaha~~~~

  After some joking, the atmosphere of several people was harmonious, and Dewey pulled Chen Qi to the side of a tall white man:

"Chen, this is Professor Segel from Karolinska University Hospital in Sweden. He is also the most famous gastroenterologist in Sweden. He has a very good relationship with Asrila Pharmaceuticals. The colleagues in the clinic helped to introduce it."

  Interpersonal relationships are so ingenious.

  You don't know people, but you can go around a few times and always find the people you need. This is the benefit of having connections.

  Chen Qi thought to himself, it really is Dr. Mayo who is number one in the world, so he just helped to introduce a "middleman", and he was looking for the top doctor in his country.

"Hello, Professor Segel, it is a great honor to meet you. Let me introduce, this is my wife, who is also a physician in our country. She once published an article in the "Lancet" magazine in 1983. Bacillus" paper."

  Professor Segel's eyes lit up when he heard this:

"Ha, I've read this paper, it's very innovative, but now the controversy seems to be very big, the main controversy is that even if this kind of bacteria is found, there is no way to prove its pathogenicity, and there is no way to kill it Unknown bacteria."

   Obviously, this Professor Segel is also an "old otaku". As soon as he meets his peers, he immediately discusses academic issues.

   This is obviously what Chen Qi likes.

  So he took a step back, highlighted his wife's position, and gave her an encouraging look.

  Lan Lijuan took a deep breath, suppressed the tension in her heart, and replied in English:

   "Hello, Professor Segel, my current experiments in China have been able to confirm the pathogenic principle of this bacterium, and the relevant papers have been completed, and I am going to continue to submit them to The Lancet.

   And we are also looking for a solution that can completely kill the bacteria in the gastric mucosa. This is why my husband and I came to Sweden, so we are very eager to get your help. "

   "What? This is incredible, can it really confirm the pathogenic factors of these unknown bacteria?"

  Professor Segel looked like he was alive. He is a top gastroenterologist, and he understands that if this argument can be confirmed, it will have great clinical significance.

   It can be said that it has subversive significance in the history of digestive diseases in the world.

  Lan Lijuan was very serious: "It's true, and my husband and I came to Sweden this time to find a drug that can kill this unknown bacterium."

  Professor Segel wanted to continue asking questions, but Dewey next to him quickly interrupted:

   "Hey, I said, are you going to have an academic meeting in the lobby? Segel, Chen and his beautiful wife are already very tired after flying for more than ten hours. Let's go and have a rest first."

  Professor Segel obviously can't wait.

  (end of this chapter)